Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells
oleh: Wenrui Wang, Lingyu Zhang, Tiantian Chen, Wen Guo, Xunxia Bao, Dandan Wang, Baihui Ren, Haifeng Wang, Yu Li, Yueyue Wang, Sulian Chen, Baoding Tang, Qingling Yang, Changjie Chen
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2017-10-01 |
Deskripsi
In this study, resveratrol-loaded solid lipid nanoparticles (Res-SLNs) were successfully designed to treat MDA-MB-231 cells. The Res-SLNs were prepared using emulsification and low-temperature solidification method. The Res-SLNs were spherical, with small size, negative charge, and narrow size distribution. Compared with free resveratrol, the Res-SLNs displayed a superior ability in inhibiting the proliferation of MDA-MB-231 cells. In addition, Res-SLNs exhibited much stronger inhibitory effects on the invasion and migration of MDA-MB-231 cells. Western blot analysis revealed that Res-SLNs could promote the ratio of Bax/Bcl-2 but decreased the expression of cyclinD1 and c-Myc. These results indicate that the Res-SLN may have great potential for breast cancer treatment.