Synthesis of spiropyridazine-benzosultams by the [4 + 2] annulation reaction of 3-substituted benzoisothiazole 1,1-dioxides with 1,2-diaza-1,3-dienes
oleh: Wenqing Hao, Long Wang, Jinlei Zhang, Dawei Teng, Guorui Cao
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2024-02-01 |
Deskripsi
A simple and efficient method for the synthesis of spiropyridazine-benzosultams has been developed by means of [4 + 2] annulation reaction of 3-substituted benzoisothiazole 1,1-dioxides with 1,2-diaza-1,3-dienes. This approach displays advantages such as mild reaction conditions, wide substrate range tolerance, simple operation, compatibility with gram-scale preparation.