Immunological fingerprint of 4CMenB recombinant antigens via protein microarray reveals key immunosignatures correlating with bactericidal activity
oleh: E. Bartolini, E. Borgogni, M. Bruttini, A. Muzzi, M. Giuliani, S. Iozzi, R. Petracca, M. Martinelli, S. Bonacci, S. Marchi, C. Brettoni, C. Donati, G. Torricelli, S. Guidotti, M. Domina, C. Beninati, G. Teti, F. Felici, R. Rappuoli, F. Castellino, G. Del Giudice, V. Masignani, M. Pizza, D. Maione
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
4CMenB is an approved multi-component vaccine against Serogroup B meningococcus. Here the authors develop a protein microarray for three major 4CMenB antigenic components (fHbp, NHBA and NadA) and describe antibody repertoires in sera from vaccinated infants, adolescents and adults correlating with bactericidal response.