Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

oleh: Wendan Ren, Jiuwei Lu, Mengjiang Huang, Linfeng Gao, Dongxu Li, Gang Greg Wang, Jikui Song

Format: Article
Diterbitkan: Nature Portfolio 2019-11-01

Deskripsi

The N6-methyladenosine (m6A) RNA modification is an evolutionarily conserved epitranscriptomic mechanism that impacts several cellular processes. Here the authors present a structure-function analysis of the ZCCHC4, 28S RNA-specific m6A methyltransferase, shedding light on its regulation and mechanisms that ensure substrate specificity.