Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification
oleh: Philip D. Dunne, Matthew Alderdice, Paul G. O'Reilly, Aideen C. Roddy, Amy M. B. McCorry, Susan Richman, Tim Maughan, Simon S. McDade, Patrick G. Johnston, Daniel B. Longley, Elaine Kay, Darragh G. McArt, Mark Lawler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-05-01 |
Deskripsi
Tumour expression profiling is currently used for prognostic and predictive purposes without taking into account the intra patient heterogeneity. Here the authors show that cancer cell specific signatures overcome the tumour heterogeneity effect and result in better classification of colorectal cancer patients.