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Background: The infiltration of neoplastic leukocytes or their progenitors into the epidermis, dermis, or subcutis, resulting in clinically evident cutaneous lesions, is known as leukemia cutis. Leukemia cutis may arise after, before, or concurrently with a diagnosis of systemic leukemia. Case Report: We present a case of congenital leukemia cutis that was later diagnosed as acute myeloid leukemia. Discussion: Congenital leukemia is defined as leukemia that is present at birth or develops within the first 6 weeks of life. Leukemia cutis has been identified in 25%–30% of patients with congenital leukemia. Typical clinical features often include papules, macules, and nodules.