Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer
oleh: Ariane F. Busso-Lopes, Leandro X. Neves, Guilherme A. Câmara, Daniela C. Granato, Marco Antônio M. Pretti, Henry Heberle, Fábio M. S. Patroni, Jamile Sá, Sami Yokoo, César Rivera, Romênia R. Domingues, Ana Gabriela C. Normando, Tatiane De Rossi, Barbara P. Mello, Nayane A. L. Galdino, Bianca A. Pauletti, Pammela A. Lacerda, André Afonso N. Rodrigues, André Luis M. Casarim, Reydson A. de Lima-Souza, Ingrid I. Damas, Fernanda V. Mariano, Kenneth J. Gollob, Tiago S. Medina, Nilva K. Cervigne, Ana Carolina Prado-Ribeiro, Thaís Bianca Brandão, Luisa L. Villa, Miyuki Uno, Mariana Boroni, Luiz Paulo Kowalski, Wilfredo Alejandro González-Arriagada, Adriana F. Paes Leme
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
The biological understanding of poor prognosis associated with lymph node metastasis in head and neck cancer (HNC) remains crucial. Here, a proteomic characterisation of 140 multisite samples from a 59-HNC patient cohort and machine learning reveals potential biomarkers and metastasis related signatures.