Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections

oleh: Pinkus Tober-Lau, Henning Gruell, Kanika Vanshylla, Willi M. Koch, David Hillus, Philipp Schommers, Isabelle Suárez, Norbert Suttorp, Leif Erik Sander, Florian Klein, Florian Kurth

Format: Article
Diterbitkan: Centers for Disease Control and Prevention 2022-05-01

Deskripsi

To determine neutralizing activity against the severe acute respiratory syndrome coronavirus 2 ancestral strain and 4 variants of concern, we tested serum from 30 persons with breakthrough infection after 2-dose vaccination. Cross-variant neutralizing activity was comparable to that after 3-dose vaccination. Shorter intervals between vaccination and breakthrough infection correlated with lower neutralizing titers.