Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

oleh: Hamidreza Jafarinia, Ali Khalilimeybodi, Jorge Barrasa-Fano, Stephanie I. Fraley, Padmini Rangamani, Aurélie Carlier

Format: Article
Diterbitkan: Nature Portfolio 2024-08-01

Deskripsi

Abstract YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.