Determining the predictive impact of donor parity on the outcomes of human leukocyte antigen matched hematopoietic stem cell transplants: a retrospective, single-center study

oleh: Mojtaba Azari, Mojtaba Azari, Maryam Barkhordar, Maryam Barkhordar, Tanaz Bahri, Tanaz Bahri, Soroush Rad, Soroush Rad, Hosein Kamranzadeh Fumani, Hosein Kamranzadeh Fumani, Seied Asadollah Mousavi, Seied Asadollah Mousavi, Sahar Tavakoli Shiraji, Sahar Tavakoli Shiraji, Morteza Azari, Morteza Azari, Parisa Shafaroudi, Parisa Shafaroudi, Mohammad Vaezi, Mohammad Vaezi

Format: Article
Diterbitkan: Frontiers Media S.A. 2024-02-01

Deskripsi

IntroductionDonor choosing remains to play a pivotal role in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Numerous criteria beyond HLA compatibility impact the selection of a suitable donor.MethodsWe evaluated the effect of donor parity on transplant outcomes in a large homogeneously treated population that received an HLA-matched allo-HSCT between 2010 and 2021 at our center. All patients were transplanted from a peripheral blood stem cell source following a myeloablative Busulfan-based conditioning and an identical protocol for graftversus-host disease (GVHD) prophylaxis regimen.ResultsA total of 1103 allo-HSCT recipients were included. 188 (17%) had transplants from parous female donors, whereas 621 (56.30%) and 294 (26.70%) received transplants from male and nulliparous female donors, respectively. HSCTs from parous female donors compared to male and nulliparous females were associated with a significantly higher incidence of grade III-IV acute (a) GVHD (55.27% vs. 11.34 and 10.84%) and extensive chronic (c) GVHD (64.32% vs. 15.52 and 13.65%), as well as lower relapse incidence (RI).DiscussionThis study finds that while parous female donors are associated with higher incidences of grade III-IV aGVHD and extensive cGVHD post-allo-HSCT, the advantages, such as a lower RI, outweigh the risks. The results of our study provide valuable insights for donor selection.