Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy
oleh: Xiaolei Pan, Naveed Ahmed, Joyce Kong, Dong Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2017-11-01 |
Deskripsi
We recently reported that depletion of FANCM in ALT cells induces replication stress mainly at their telomeres. Additionally, we found that co-depletion of FANCM and BLM, or FANCM and BRCA1 induces synthetic lethality in the ALT cells. Our new findings could have important implications for cancer prevention and treatment.