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This work presents the design of a low power upconversion mixer adapted in medical remote sensing such as wireless endoscopy application. The proposed upconversion mixer operates in ISM band of 433 MHz. With the carrier power of −5 dBm, the proposed mixer has an output inferred 1 dB compression point of −0.5 dBm with a corresponding output third-order intercept point (OIP3) of 7.1 dBm. The design of the upconversion mixer is realized on CMOS 0.13 μm platform, with a current consumption of 594 μA at supply voltage headroom of 1.2 V.