Structural and regulatory diversity shape HLA-C protein expression levels
oleh: Gurman Kaur, Stephanie Gras, Jesse I. Mobbs, Julian P. Vivian, Adrian Cortes, Thomas Barber, Subita Balaram Kuttikkatte, Lise Torp Jensen, Kathrine E. Attfield, Calliope A. Dendrou, Mary Carrington, Gil McVean, Anthony W. Purcell, Jamie Rossjohn, Lars Fugger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
HLA-C expression levels correlate with immune responses to pathogens and autoimmunity, and vary in an allele-specific manner across individuals. Here the authors identify factors that drive differential expression of HLA-C allomorphs at the cell surface, and influence the structure of the peptide-binding cleft and diversity of peptides bound by HLA-C molecules.