Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack
oleh: Shuang Yang, Giorgos Hiotis, Yi Wang, Junjian Chen, Jia-huai Wang, Mikyung Kim, Ellis L. Reinherz, Thomas Walz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
The membrane-proximal external region of HIV-1 spike protein is a broadly neutralizing antibody target. Here, cryo-electron microscopy and molecular dynamics reveal spontaneous ectodomain tilting, a vulnerability exploitable for vaccine design.