PKCɛ switches Aurora B specificity to exit the abscission checkpoint
oleh: Tanya Pike, Nicola Brownlow, Svend Kjaer, Jeremy Carlton, Peter J. Parker
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-12-01 |
Deskripsi
The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit Borealin phosphorylation and abscission checkpoint exit.