Oxidation and alkylation stresses activate ribosome-quality control
oleh: Liewei L. Yan, Carrie L. Simms, Fionn McLoughlin, Richard D. Vierstra, Hani S. Zaher
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-12-01 |
Deskripsi
The mRNA-surveillance pathway of no-go decay (NGD) is a eukaryotic ribosome-based-quality-control process that targets transcripts that stall the ribosome. Here the authors show no-go decay (NGD) and ribosome-quality control (RQC) pathways are activated by mRNAs damaged by alkylation and oxidation stress.