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Canine pyometra is a hormonally mediated life-threatening uterine disease of canines, associated with bacterial infection and inflammation. The disease is characterized by the accumulation of pus in the uterus and systemic illness. The study was undertaken to assess the relevance of band cells in circulation and Doppler ultrasonography in the prognostic evaluation of medically managed canine pyometra. A significantly higher band of neutrophils were recorded among bitches presented with pyometra, which reduced to the physiologically normal range as treatment progressed in the animals which responded to the treatment. The resistive index, which was lower than the threshold value of 0.72, increased as the treatment progressed in the responsive animals and proved to be a reliable tool as a recovery marker.