Systematic detection of functional proteoform groups from bottom-up proteomic datasets
oleh: Isabell Bludau, Max Frank, Christian Dörig, Yujia Cai, Moritz Heusel, George Rosenberger, Paola Picotti, Ben C. Collins, Hannes Röst, Ruedi Aebersold
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Many proteins exist in various proteoforms but detecting these variants by bottom-up proteomics remains difficult. Here, the authors present a computational approach based on peptide correlation analysis to identify and characterize proteoforms from bottom-up proteomics data.