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BackgroundNeurodegenerative diseases induce amnesia, and effective treatment is still elusive. Aims and Objectives: The present study highlights the ameliorating effects of Manasa Mitra Vatakam (MMV) using behavioral parameters on scopolamine-induced memory loss in female Wistar rats. Materials and MethodsMMV was compared with DPZ as a standard in the present study to determine the behavioral parameters through elevated plus maze (Hebb William maze/rectangular maze)and locomotor activity in scopolamine-induced memory loss in female Wistar rats. Results and DiscussionThe results of the study illustrate the effectiveness of MMV in reversing memory dysfunction and memory-enhancing effects. ConclusionThe study paves the way for exploring research in CNS disorders and its potential application in drug-induced neurotoxicity.