Exploring the Antiradical Potential of Species from Lamiaceae Family: Implications for Functional Food Development in the Context of Neurodegenerative and Neuropsychiatric Diseases

oleh: Ana Campinho, Joana Alves, Rosário Martins, Mónica Vieira, Clara Grosso, Cristina Delerue-Matos

Format: Article
Diterbitkan: MDPI AG 2023-10-01

Deskripsi

Neurodegenerative and neuropsychiatric diseases have become highly significant in Western societies. Unfortunately, these diseases currently lack a cure, and existing treatments merely manage the symptoms. Thus, it is imperative to explore new alternatives for either preventing these disorders or treating them effectively. One promising avenue for prevention lies in the development of neuroprotective and antioxidant functional foods. To this end, a study focused on ten species from the Lamiaceae family, which have attracted attention due to their well-known antioxidant, anti-inflammatory, anti-obesity, and anti-cancer properties, among others. The interest in their pharmacological applications has grown significantly in recent years. In order to uncover the biological potential of these species, the study involved performing decoctions and evaluating both the total phenolic content (TPC) and antiradical activity. The results revealed that TPC values ranged from 59.97 ± 6.18 (<i>Ocimum basilicum</i> L. var <i>minimum</i>) to 374.0 ± 16.9 (<i>Salvia officinalis</i> L.) mg gallic acid equivalents (GAE)/g of dry extract (dw). Additionally, the IC<sub>50</sub> values for DPPH<sup>•</sup> and ABTS<sup>•+</sup> scavenging activities varied between 21.55 ± 1.18 (<i>Origanum vulgare</i> L.) and 132.0 ± 15.3 μg/mL (<i>O. basilicum</i> var <i>minimum</i>), and from 14.79 ± 0.50 (<i>O. vulgare</i>) to 44.65 ± 2.34 μg/mL (<i>O. basilicum</i>), respectively. The observed strong antiradical activity holds great promise for the future development of functional foods aimed at combating the oxidative stress implicated in these diseases and promoting overall brain health. By harnessing the potential of these species from Lamiaceae family, we may pave the way for innovative approaches to tackle neurodegenerative and neuropsychiatric conditions.