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Stellaria media Linn., a member of the family Caryophyllaceae, is generally known by the name of Chickweed. This plant is extensively cultivated globally and is inherent to Africa, Asia, China, Europe, and North America. It is a well-known medicinal plant with immense therapeutic uses. Nutritional studies have revealed the presence of protein, especially 16 amino acids, vitamins, and minerals such as calcium, iron, phosphorus, and zinc. Phytochemicals, mainly flavonoids, isoflavonoids, saponins, tannins, alkaloids, phenolic acids, triterpenoids, phenolic compounds, and anthraquinone are present in chickweed. It has multiple therapeutic potentials like anti-obesity, anti-diabetic, anti-fungal, anti-bacterial, anti-inflammatory, anti-leishmanial, anti-anxiety, and toxicity profiles. The crude extracts and their metabolites did not show any toxicity in the experimental animal. This review summarizes the nutritional, phytochemical, pharmacological, and toxicity studies on this plant concerning its future use in pharmacological drugs.