Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation
oleh: Wanzun Lin, Li Chen, Haojiong Zhang, Xianxin Qiu, Qingting Huang, Fangzhu Wan, Ziyu Le, Shikai Geng, Anlan Zhang, Sufang Qiu, Long Chen, Lin Kong, Jiade J. Lu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
YTHDF1 is an m6A reader that binds to methylated RNA and facilitates translation. Here the authors show that tumor intrinsic YTHDF1 promotes tumorigenesis by regulating lysosomal proteolysis of MHC-I and that YTHDF1 targeting boosts anti-tumor immunity and response to immunotherapy in preclinical cancer models.