Find in Library

The emergence of multidrug resistant bacterial pathogens and the increase of antimicrobial resistance constitutes a major health challenge, leading to intense research efforts being focused on the discovery of novel antimicrobial compounds. In this study, endophytes were isolated from different parts of <i>Sandwithia guyanensis</i> plant (leaves, wood and latex) belonging to the Euphorbiaceae family and known to produce antimicrobial compounds, and chemically characterised using Molecular Network in order to discover novel antimicrobial molecules. One fungal endophyte extract obtained from <i>S. guyanensis</i> latex showed significant antimicrobial activity with Minimal Inhibitory Concentration on methicillin-resistant <i>Staphylococcus aureus</i> at 16 &#181;g/mL. The chemical investigation of this fungus (<i>Lecanicillium</i> genus) extract led to the isolation of 5 stephensiolides compounds, four of which demonstrated antibacterial activity. Stephensiolide I and G showed the highest antibacterial activity on MRSA with a MIC at 4 and 16 &#181;g/mL respectively.