A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
oleh: Shipo Wu, Gongxun Zhong, Jun Zhang, Lei Shuai, Zhe Zhang, Zhiyuan Wen, Busen Wang, Zhenghao Zhao, Xiaohong Song, Yi Chen, Renqiang Liu, Ling Fu, Jinlong Zhang, Qiang Guo, Chong Wang, Yilong Yang, Ting Fang, Peng Lv, Jinliang Wang, Junjie Xu, Jianmin Li, Changming Yu, Lihua Hou, Zhigao Bu, Wei Chen
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-08-01 |
Deskripsi
A vaccine preventing infection and transmission of SARS-CoV-2 is needed. Here, Wu et al. generate an adenovirus-vector vaccine expressing SARS-CoV-2 spike protein and show that a single dose of mucosal vaccination protects mice and ferrets from infection and inhibits virus replication in the upper respiratory tract.