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Cognitive processes of apathy in Huntington’s disease show high sensitivity to disease progression
oleh: Emily Hare, Anne-Catherine Bachoud-Lévi, Ralf Reilmann, David Craufurd, Monica Busse, Anne Rosser, Duncan McLauchlan
Format: | Article |
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Diterbitkan: | Elsevier 2022-01-01 |
Deskripsi
Background: Disease-modifying treatments for Huntington’s disease (HD) are entering clinical trials: there is a pressing need for objective outcome measures of disease progression. Our previous work showed an association between 2 novel, objective cognitive tasks and apathy - a core feature of disease progression in HD. Objective: Evaluate the longitudinal validity and sensitivity of the novel Persistence and Maze tasks to assess their utility as clinical outcome measures in HD. Methods: 83 participants positive for the HD gene and 54 controls performed a battery of established and novel tools, at baseline and 12 month follow up. Results: The Maze task was found to be the most sensitive measure of change at 12 months, including the current gold-standard measure (the composite disease progression score). Conclusion: The Maze task has potential as a novel outcome measure of disease progression in HD and may have utility in other major neurodegenerative diseases.