Parameter identifiability of a within-host SARS-CoV-2 epidemic model

oleh: Junyuan Yang, Sijin Wu, Xuezhi Li, Xiaoyan Wang, Xue-Song Zhang, Lu Hou

Format: Article
Diterbitkan: KeAi Communications Co., Ltd. 2024-09-01

Deskripsi

Parameter identification involves the estimation of undisclosed parameters within a system based on observed data and mathematical models. In this investigation, we employ DAISY to meticulously examine the structural identifiability of parameters of a within-host SARS-CoV-2 epidemic model, taking into account an array of observable datasets. Furthermore, Monte Carlo simulations are performed to offer a comprehensive practical analysis of model parameters. Lastly, sensitivity analysis is employed to ascertain that decreasing the replication rate of the SARS-CoV-2 virus and curbing the infectious period are the most efficacious measures in alleviating the dissemination of COVID-19 amongst hosts.