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Parameter identifiability of a within-host SARS-CoV-2 epidemic model
oleh: Junyuan Yang, Sijin Wu, Xuezhi Li, Xiaoyan Wang, Xue-Song Zhang, Lu Hou
Format: | Article |
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Diterbitkan: | KeAi Communications Co., Ltd. 2024-09-01 |
Deskripsi
Parameter identification involves the estimation of undisclosed parameters within a system based on observed data and mathematical models. In this investigation, we employ DAISY to meticulously examine the structural identifiability of parameters of a within-host SARS-CoV-2 epidemic model, taking into account an array of observable datasets. Furthermore, Monte Carlo simulations are performed to offer a comprehensive practical analysis of model parameters. Lastly, sensitivity analysis is employed to ascertain that decreasing the replication rate of the SARS-CoV-2 virus and curbing the infectious period are the most efficacious measures in alleviating the dissemination of COVID-19 amongst hosts.