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Applied exercise physiology is a rich profession in much of the developed world in the early 21st century.  However, in the early 1970’s there was no such profession, just the scientific discipline of exercise physiology.  Linked to the 1975 publication of the first edition of ACSM’s Guidelines for Graded Exercise Testing and Exercise Prescription, the authors career has been linked to a serendipitous series of events that have seen the development of the profession of applied exercise physiology.  Taken as a whole, these parallel stories inform us of the importance of serendipity within the process of scientific discovery.