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The aim of the work to detect the level of Cyclophilin-D in psoriasis and its correlation with disease severity. Samples included 84 persons divided into 2 groups (42) patients having psoriasis and (42) apparently healthy age and sex-matched individuals. All individuals included in the study were subjected to full history, full clinical examination, 3 cm of blood had been taken from patients of psoriasis and matched controls and centrifuged for serum separation which kept frozen at -80c till analysis of Cyclophilin-D by ELISA technique.