Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
oleh: Gal Cafri, Rami Yossef, Anna Pasetto, Drew C. Deniger, Yong-Chen Lu, Maria Parkhurst, Jared J. Gartner, Li Jia, Satyajit Ray, Lien T. Ngo, Mohammad Jafferji, Abraham Sachs, Todd Prickett, Paul F. Robbins, Steven A. Rosenberg
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
Adoptive cell therapy (ACT) using neoantigen-specific T cells can lead to tumor regression. Here the authors use an in vitro stimulation approach to isolate tumor specific memory T cells from peripheral blood of metastatic epithelial cancer patients targeting unique as well as shared mutations in the KRAS oncogene.