Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
oleh: Hao Zuo, Dengbao Yang, Qiwen Yang, Haidong Tang, Yang-Xin Fu, Yihong Wan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-03-01 |
Deskripsi
The effect of PARP inhibitors on bone mass and bone metastasis are unclear. Here, the authors show that PARP1/2 dual inhibitors may increase cancer bone metastasis through PARP2-dependent regulation of immature myeloid cells, and cause bone loss through PARP1/2-dependent regulation of osteoclasts.