Research progress of NT5C2 in disease and treatment
oleh: SHU Ling, HUO Bennian, SONG Lin
| Format: | Article |
|---|---|
| Diterbitkan: | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2023-05-01 |
Deskripsi
Cytosolic 5'-nucleotidase Ⅱ(cN-Ⅱ), the protein encoded by NT5C2, can catalyze the dephosphory-lation of nucleoside monophosphate and is mainly involved in the regulation of purine nucleotide pool in cells. High expression of cN-Ⅱ mRNA is associated with poor prognosis of patients with acute leukemia (AL). Acquired NT5C2 mutation will hinder the formation of DNA and thioguanine nucleotide (TGN) conjugate, resulting in 6-mercaptpurine(6-MP) resistance. In addition, NT5C2 is a risk factor associated with type Ⅱ diabetes, schizophrenia and other diseases.