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This paper illustrates the application of a severe accident analysis computer program to the uncertainty analysis of molten corium-concrete interaction (MCCI) phenomena in cases of severe accidents in CANDU6 type plant. The potential hazard of MCCI is a failure of the reactor building owing to the possibility of a calandria vault floor melt-through even though the containment filtered vent system is operated. Meanwhile, the MCCI still has large uncertainties in several phenomena such as a melt spreading area and the extent of water ingression into a continuous debris layer. The purpose of this study is to evaluate the MCCI in the calandria vault floor via an uncertainty analysis using the ISAAC program for the CANDU6.