An efficient approach to angular tricyclic molecular architecture via Nazarov-like cyclization and double ring-expansion cascade
oleh: Yun-Peng Wang, Kun Fang, Yong-Qiang Tu, Jun-Jie Yin, Qi Zhao, Tian Ke
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Effective methods for accessing polycarbocycles are scarcely reported and generally involve complex, multistep transformations, thus restricting practical utility. Here, the authors construct tri-to-penta- cyclic frameworks containing at least two quaternary carbon centers via a tandem Nazarov-like cyclization / double cycloexpansion of simple 1,3-dicyclobutylidene ketone substrates.