Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes
oleh: Adam B. Weiner, Thiago Vidotto, Yang Liu, Adrianna A. Mendes, Daniela C. Salles, Farzana A. Faisal, Sanjana Murali, Matthew McFarlane, Eddie L. Imada, Xin Zhao, Ziwen Li, Elai Davicioni, Luigi Marchionni, Arul M. Chinnaiyan, Stephen J. Freedland, Daniel E. Spratt, Jennifer D. Wu, Tamara L. Lotan, Edward M. Schaeffer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
A recent report suggested Black men with prostate cancer were more responsive to immunotherapy. Here, the authors analysed prostate cancer gene expression profiles and show tumours from Black men and men with African ancestry have an increased proportion of plasma cells compared to those of White men and this correlates with improved outcome following treatment.