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Introduction: Reconstruction of frontal deformities is challenging for surgeons, with the search for materials and techniques that offer a more comfortable and optimal result being a significant issue. This report describes the reconstruction of a large frontal defect caused by a mucocele using a titanium mesh and rib cartilage. Case: A 44-year-old female with a left frontal ethmoid mass was suspected of having a mucocele with a frontal defect and optic nerve compression. The patient underwent drainage, endoscopic marsupialization of the mucocele, and reconstruction of the frontal defect using a combination of a rib graft and titanium mesh. The patient showed no complications or functional or esthetic complaints over one year of follow-up. Discussion: Autologous bony cartilage has great growth potential and functions best when integrated into the natural bone, indicating a reduced risk of graft loss. Titanium is a non-inflammatory, biocompatible metal that is helpful for the quick repair of large cranial defects. In the present case, the frontal defect was large. Therefore, we decided to use a rib graft combined with a titanium mesh as a bridge to close the defect. Conclusion: Reconstruction of a frontal defect using a combination of autologous rib grafts and titanium mesh showed excellent results in the current case.