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Background: GBM is the most common and malignant astrocity tumor and it is persistent to common treatment so, these patients have a very low survival. Several researchers around the world, including Iran, have been investigated GBM-cell line in vitro. However in vivo studies have not been fulfilled. Methods: As standard cell line (U-87MG) derived from human GBM and total GBM tumor derived from 3 patients were heterotypic ally injected into 4-6 weeks old athymic nude mice.  Pathologic investigation by H&E, GFAP and Ki-67 were examined 2 months post implantation. Results: GBM characteristics appeared in H&E and GFAP and the rate of proliferation was 6% and in direct xenograft tumor was 9% which was consistent with the pathologic result of patient. Conclusion: GBM Xengraft is the most suitable model for in vivo investigation and researcher can evaluate new treatments for this tumor. On the other hands, Pharmacogenomics differences in treatment response could be indicated among Iranians.