Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status
oleh: Guido Finazzi, Alessandro Rambaldi, Vittoria Guerini, Alessandra Carobbo, Tiziano Barbui
| Format: | Article |
|---|---|
| Diterbitkan: | Ferrata Storti Foundation 2007-01-01 |
Deskripsi
We compared the laboratory and clinical findings of 179 patients with essential thrombocythemia (ET) and 77 with polycythemia vera (PV) classified according to the presence of the JAK2 V617F mutation. A gradient between patients with JAK2 wild-type ET, JAK2 V617F ET and PV (all carrying the JAK2 mutation) was observed. The rate of thrombotic complications in JAK2-positive ET was significantly higher than in wild-type ET and not statistically different from that of PV patients.