Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase
oleh: Sebenzile K. Myeni, Peter J. Bredenbeek, Robert C. M. Knaap, Tim J. Dalebout, Shessy Torres Morales, Igor A. Sidorov, Marissa E. Linger, Nadia Oreshkova, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Luis Enjuanes, Isabel Sola, Eric J. Snijder, Marjolein Kikkert
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
In this work, authors provide a proof-of-concept study showing that deubiquitinating enzyme inactivation in MERS-CoV leads to attenuation in mice, and protection against a lethal challenge.