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BackgroundThin endometrium is one of the crucial reasons leading to the reduction of pregnancy rate in patients. The whole embryo freezing is an important strategy in the process of assisting pregnancy in patients with thin endometrium. However, there are still controversies regarding the choice of subsequent freeze-thaw embryo transfer.ObjectiveTo explore the difference between two endometrial preparation programs〔artificial cycle and gonadotropin releasing hormone agonist (GnRH-a) down regulating artificial cycle〕 independent of endogenous ovarian cycle in patients with thin endometrial.MethodsA retrospective analysis of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) assisted pregnancy treatment was performed in the Reproductive Center of Henan Provincial People's Hospital from December 2016 to July 2019. The whole embryo was frozen due to endometrial thickness less than 7 mm in the month of egg collection, then the clinical data of the freezing-thawing embryo transfer patients were collected by artificial cycle (artificial cycle group, n=409) and GnRH-a down-regulated artificial cycle (GnRH-a down-regulated artificial cycle group, n=103) . Pregnancy results were compared between the two groups of patients.ResultsThe average number of transplanted embryos in the artificial cycle group was (1.60±0.49) , while that in the GnRH-a daon-regulated artificial cycle group was (1.66±0.52) , and there was no statistically significant difference between the two groups (P>0.05) . In the artificial cycle group, there were no significant differences in clinical pregnancy rate, implantation rate, abortion rate, ectopic pregnancy rate and multiple pregnancy rate among those with 1, 2 and 3 embryos transferred, respectively (P>0.05) . In the GnRH-a down-regulated artificial cycle group, there were also no significant differences in clinical pregnancy rate, implantation rate, abortion rate, ectopic pregnancy rate and multiple fetus rate among those with 1, 2 and 3 embryos transferred, respectively (P>0.05) .ConclusionIn patients with thin endometrium thickness (≤7 mm) , two endometrial preparation programs (artificial cycle and GnRH-a) independent of endogenous ovarian cycle had similar results in regulating artificial cycle pregnancy. It is not recommended to use GnRH-a combined with hormone replacement in the endometrial preparation program of conventional thin endometrial patients without special medical history such as endometriosis and repeated implant failure.