N 6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis
oleh: Xiaojie Ma, Jie Cao, Ziyu Zhou, Yunkun Lu, Qin Li, Yan Jin, Guo Chen, Weiyun Wang, Wenyan Ge, Xi Chen, Zhensheng Hu, Xiao Shu, Qian Deng, Jiaqi Pu, Chengzhen Liang, Junfen Fu, Jianzhao Liu, Saiyong Zhu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Ma et al. profile the dynamic landscape of m6A during pancreatic differentiation, and identify ALKBH5 as an essential m6A regulator supporting pancreatic differentiation, indicating a role for m6A-mediated mRNA metabolism in cell-fate specification.