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An increasing focus in cancer therapy is on the investigation of fungal products with anticancer activity and potential to affect specific targets. Main goal of this study is the analysis of the effects of <i>Phellinus linteus</i> and <i>Lentinus edodes,</i> edible and medicinal mushrooms, on the significant migratory/invasive markers in the first steps of cancer metastasis. Both treatments increased antimigratory marker E-cadherin and decreased promigratory/proinvasive proteins N-cadherin and Vimentin. A lowered concentration of proinvasive protein MMP-9 was also observed in treated HCT-116 and SW-480 cells. <b>PL</b> and <b>LE</b> exerted cell selectivity, whereas <b>PL</b> had better activity on SW-480, while <b>LE</b> had a more prominent effect on HCT-116 cells.