Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
oleh: Pierre Bigot, Leandro M. Colli, Mitchell J. Machiela, Lea Jessop, Timothy A. Myers, Julie Carrouget, Sarah Wagner, David Roberson, Caroline Eymerit, Daniel Henrion, Stephen J. Chanock
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-07-01 |
Deskripsi
A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.