BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis
oleh: Jing-zun Xu, Yan-man Zhou, Lin-lin Zhang, Xiao-jing Chen, Yu-ying Yang, Deng Zhang, Ke-cheng Zhu, Xiao-ke Kong, Li-hao Sun, Bei Tao, Hong-yan Zhao, Jian-min Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Publishing Group 2022-05-01 |
Deskripsi
BMP9 inhibits cellular senescence by activation of Smad1, which suppresses the transcription of Stat1, resulting in decreased P21 expression and SASPs production in osteoblast. The anti-aging effect of BMP9 is benefit to improving age-related osteoporosis.