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This paper is research on the distribution system’s simulation of large company’s logistics under Internet of Things (IoT) based on traveling salesman problem solution. The authors claim that the real-time traffic synergy is better than traditional distribution strategy in general, verifying and comparing the simulation results in different situations of goals and starting time distribution. The simulation method used in this paper makes the result more scientific and reliable. The simulation truly reflects the degree of influence of information synergy to improve the efficiency of logistics system. The information synergy had an obvious enhancing effect on system operation efficiency. Taking full advantage of the value of information and improving the information synergy to the best level have irreplaceable effect on system operation efficiency.