Aggressive large B-cell lymphoma with plasma cell differentiation: immunohistochemical characterization of plasmablastic lymphoma and diffuse large B-cell lymphoma with partial plasmablastic phenotype
oleh: Santiago Montes-Moreno, Ana-Rosa Gonzalez-Medina, Socorro-María Rodriguez-Pinilla, Lorena Maestre, Lydia Sanchez-Verde, Giovanna Roncador, Manuela Mollejo, Juan F. García, Javier Menarguez, Carlos Montalbán, M. Carmen Ruiz-Marcellan, Eulogio Conde, Miguel A. Piris
| Format: | Article |
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| Diterbitkan: | Ferrata Storti Foundation 2010-08-01 |
Deskripsi
Background Plasmablastic lymphoma has recently come to be considered a distinct entity among mature B cell neoplasms, although the limits with diffuse large B-cell lymphoma (DLBCL) need to be more accurately defined.Design and Methods Here we show the results of an immunohistochemical study of 35 cases of plasmablastic lymphoma compared with a set of 111 conventional DLBCLs.Results Our results demonstrate that the use of a limited combination of immunohistochemical markers (PAX5&CD20, PRDM1/BLIMP1 and XBP1s) enables the identification of a plasmablastic immunophenotype highly characteristic of plasmablastic lymphoma cases and associated with an aggressive clinical behavior. Additionally, the study shows that the acquisition of a partial plasmablastic phenotype (PRDM1/BLIMP1 expression) in DLBCL is associated with shorter survival in R-CHOP-treated patients.Conclusions The use of a restricted combination of immunohistochemical markers (PAX5&CD20, PRDM1/BLIMP1 and XBP1s) enables a more accurate definition of terminal differentiation for large B-cell lymphoma.