mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters
oleh: Yuanhui Liu, Nancy G. Azizian, Delaney K. Sullivan, Yulin Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Chemotherapy resistance poses a major obstacle in cancer therapy. Here, the authors identify the mTOR pathway as a determinant of chemosensitivity and demonstrate that inhibition of mTOR promotes the persistence of a chemotherapy-resistant cancer-cell subpopulation.