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Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules
oleh: Valentyn Mohylyuk, David Jones, Shu Li, Yalin Ding, Gavin Patrick Andrews
Format: | Article |
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Diterbitkan: | University of Huddersfield Press 2022-11-01 |
Deskripsi
The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative simplicity of scale-up and process control. Tablets are the most popular solid dosage form, while batch granulation is one of the most often used technologies in tablet manufacturing. Using ascorbic acid as a model, we show the possibility of producing granules and tablets with a sustained-release profile using three technological operations: mixing, continuous melt-granulation, and tabletting.