Protein-Peptide Turnover Profiling reveals the order of PTM addition and removal during protein maturation
oleh: Henrik M. Hammarén, Eva-Maria Geissen, Clement M. Potel, Martin Beck, Mikhail M. Savitski
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
Metabolic labeling is often used to measure protein turnover. Here the authors show that for interconvertible protein species like phosphoforms metabolic labeling does not provide information on turnover differences, but that the relative order of modification can determine the observed dynamics.