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2,4,6-trinitrotoluene (TNT) and its derivatives are nitrogen-containing aromatic compounds having chemical and thermal stability at ambient temperature and pressure. TNT has high toxicity and mutagenic activity to humans, plants and animals, thus decontamination processes are necessary. Many microorganisms are capable to bioremediate TNT such as bacteria from the genera Pseudomonas, Enterobacter, Rhodococcus, Mycobacterium, Clostridium and Desulfovibrio; fungus such as Phanerochate and Stropharia species are able to perform TNT biotransformation under aerobic and anaerobic conditions. In this work we review the state of TNT biodegradation by various routes: aerobic, anaerobic, combined, fungal, enzymatic, and bio-electrochemical. Keywords: Laccases, Aerobic degradation, Anaerobic degradation, Fungal TNT degradation