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To estimate the influence of the rotation center eccentricity of the single-blade centrifugal pump impeller on the radial force on it, and to explore the effective radial force balance method, a single blade pump with a power of 2.2 kW is analyzed. The accuracy of Numerical Simulation Methods are verified by tests of external characteristics (under three rotation-speeds of 1470 r/min, 2000 r/min, and 2940 r/min) and pressure distributions. There are five models with different rotation center coordinates (model a with (0,1), model b with (−1,0), model c with (0,−1), model d with (1,0), and model e with (0,0.5)) which are analyzed. The results show that the radial force of model c and model d reduced by 8.1% and 9.8%, respectively, which means the offset of the center of the impeller to the positive direction of the <i>x</i>-axis and the negative direction of the <i>y</i>-axis can effectively reduce the radial force. At the eccentricity of the impeller (2,−2), the radial force under all operating conditions is reduced, most obviously at 1.0 <i>Q</i>_d, which is about 17%. The study may prove helpful to designers and pump manufacturers to find a path forward for an optimal eccentricity to minimize the radial force.